Pharmaceutical Processing Pump Seals, Agitator Seals and More | John Crane
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As an innovator in applied engineering, John Crane is well equipped to address the unique and challenging requirements of the pharmaceutical industry. We engineer our products to meet the industry’s safety and reliability standards — as well as local environmental regulations — so that our chemical processing customers can increase their uptime and lower their license fees. From clean-in-place components to batch documentation and certification of material integrity, John Crane provides pharmaceutical processing companies with the engineered components and services they need.

Field-tested Solutions

John Crane is a recognized world leader in the design, manufacture and supply of solutions for pharmaceutical processors. Our Technology Testing Centers represent the industry’s most advanced development facilities. To meet USP Class VI specifications and maintain ISO 9001:2008 certification, we test our components using element analysis tools — CSTEDY and CTRANS — that simulate seal face behavior in real-world conditions.

Through rigorous testing and continual improvement, we’ve designed a number of industry-specific components that help optimize performance, efficiency and reliability. Some address specific fluid-handling problems, while others mitigate friction, wear and contamination with non-contacting, spiral groove lift-off technology. Many of our products even provide 100 percent containment of fugitive emissions, and we have more than 200 global rapid-response facilities available anytime for service, support and repair.

Here are some of the products that we’ve specially designed to meet the needs of our pharmaceutical processing customers:

Vessel and Agitator Seals

Type 7800 Series Universal Vessel Seal: Provides maximum flexibility while ensuring that product purity standards within the vessel are met

Type 770 Rotating Seal: Proprietary dry-running carbon graphite ring design promotes extremely long runs and low maintenance requirements

Type 32i Dry-running Seal: Proprietary "Intelli-Face®" technology eliminates running noise and satisfies OSHA requirements

Split Seals

Type 75FS Dry-running Split Seal: Held together with an elastomer-cushioned retainer that completely eliminates distortion

O-ring Pusher Seals

Type 586 Double Seal: Provides self-draining, wide-open elements that are easily sterilized; exposes only minimal hardware to the process

Type 5600 Series: Modular design with full array of interchangeable seal heads and hardware to increase flexibility and simplify spare part inventory requirements

Type 4600 Series: Compact, economical single seal that provides excellent seal life

Non-contacting Seals

Type 2800 Series: Non-contacting seal eliminates liquid lubrication to ensure 100 percent product purity

Seal Support Systems

WCH/WCV/K2S: Water-cooled heat exchangers for use where water is readily available

GR1/1C: General duty reservoir that can withstand pressure up to 16.3 bar while providing buffer/barrier fluid to a dual-seal arrangement

GR2/2C: General duty reservoir that can withstand pressure up to 30 bar while providing buffer/barrier fluid to a dual-seal arrangement

GR3/3C: General duty reservoir that can withstand pressure up to 73 bar (stainless steel) or 62 bar (carbon steel) while providing buffer/barrier fluid to a dual-seal arrangement

GP-S/GP-D: Non-API gas control panel for filtering, regulating and monitoring gas supply to gas-lubricated pump seals

Cyclone Separators: Typically used in an API Plan 31 arrangement and incorporated in the seal flush line (API Plan 11 ) from the discharge of the pump

Safeunit Ultima: Specially designed to control seal water flow and pressure in extreme conditions

Safeclean: Removes impurities and particles, providing clean seal water for stuffing boxes and mechanical seals

Power Transmission Couplings

A Series: Urethane element couplings known for quick installation without moving prime mover or driven equipment


Styles 1056 and 1057: Designed with FDA-compliant PTFE fibers and lubricant to prevent contamination

CVH/CVU: Automatic packings containing no lubricants or dispersions, well suited for non-contaminating services


John Crane's Seebach Particle Filters are used to clean water from the public drinking water network at the inflow into buildings and for the fine filtration of drinking water near to the point of use. They remove suspended sand grains and particles, such as rust, flax fibres, or debris from broken seals, from the pipe system

Services for Pharmaceutical Processors

In addition to our highly engineered seals and bearings, John Crane also offers a range of services designed to help improve reliability and reduce total cost of ownership:

Equipment Service

John Crane Equipment Service assists with critical systems checks and plant equipment maintenance as well as repair, removal and reinstallation services.

Reliability Support

John Crane Reliability Support services assess equipment reliability and performance, analyze root cause failures and recommend strategies for improvement.

Asset Management

John Crane Asset Management software offers customers a holistic view of their current systems to help spot unleveraged opportunities.


John Crane provides a wide range of training courses that cover the correct procedures for installing, operating and maintaining equipment components.